Research We Fund

Research Network

Commmitment: £294,800 Start date: 2015 Duration: 3 years

Chief Investigator: Prof Huw Morris, University College London

 

Our ground-breaking collaborative network of leading research centres aims to step up the pace of PSP and CBD research in the UK. The network’s first major study, PROSPECT, is now well underway. As well as creating a bank of data and samples, it will dramatically increase understanding of disease progression and markers. Ultimately this should create a clear disease model that can used as a benchmark in future clinical trials.

 

Development of a cerebrospinal fluid (CSF) biobank and CSF biomarkers for PSP

Commitment: £184,697 Start date: 2017 Duration: 2 years

Chief Investigator: Prof Huw Morris, University College London

 

This funding will support the collection and analysis of spinal fluid samples from PROSPECT study participants (see Research Network). The project aims to identify biological markers of disease in spinal fluid, which will help secure more rapid diagnosis and better tracking of disease progression. This in turn will assist patient monitoring in future clinical trials.

 

PSP Research Network neuroimaging core

Commitment: £300,000 Start date: 2016 Duration: 3 years

Chief Investigator: Prof James Rowe, University of Cambridge

 

This funding will allow the integration of a brain imaging study with the PROSPECT project (see Research Network). Using cutting-edge brain scanning technology and analysis, the researchers will be able to use images alongside the rest of the data collected from PROSPECT participants to improve understanding of how PSP and CBD arise and spread through the brain. It will also develop the use of brain scans as a tool for diagnosis and monitoring.

 

MAPT-PSP: clinicopathological correlations and biomarker evaluation of a tau radioligand in PSP in

preparation for clinical trials

 

Commitment: £93,105 Start date: 2015 Duration: 2 years

Chief Investigator: Prof James Rowe, University of Cambridge

 

In PSP, the protein tau changes chemically and clumps together in brain cells. Until recently, could not be seen until after death. The researchers will use a new injectable dye which can be seen using a PET brain scanner, to visualise the damaging tau in living patients. They will test the sensitivity of the technique, whether it relates to the severity of the disease and whether it can distinguish PSP from other conditions. This could ultimately speed up accurate diagnosis and help assess the effect of new drugs in clinical trials.

 

Fellowships:

 

The development of young researchers is essential for the future of PSP and CBD research. Fellowships enable young doctors to undertake a clinical research project, providing them with the skills and experience to bridge the gap between the lab and clinic in their future careers. This will be essential to enable them to facilitate the development of treatments.

 

Scottish Research Fellowship (co-funded by Scottish Chief Scientist Office)

Commitment £97,500 Start date: 2016 Duration: 3 years

Fellow: Dr Diane Swallow, University of Aberdeen

 

Sarah Koe Research Fellowship

Commitment £210,000 Start date: 2016 Duration: 3 years

Fellow: Dr Edwin Jabbari, University College London

 

Queen Square Brain Bank

£20,000 annually

 

Brain banks provide a unique resource for researchers, enabling them to develop their understanding of disease through the study of donated brain tissue. The Queen Square Brain Bank at University College London holds the largest collection of PSP and CBD brains in the UK and the second largest in the world. Find out more about brain donation.